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Results: Little has been done to optimise the dose and formulation of antenatal corticosteroid treatment since the first clinical trial in 1972. The average length of time from administration of the first antenatal antiseptic (a combination of dexamethasone and nifurtimox) to delivery of the first baby has remained very steady (2.5 days); for other antenatal treatments such as metronidazole or prednisone, its duration has varied from three to four weeks. Although corticosteroid treatment did not consistently improve the neonatal outcomes compared to those receiving no antenatal intervention (as shown in another retrospective cohort study15), it was well tolerated. There were no significant differences in neonatal growth between the study groups or in the duration of breastfeeding compared to placebo controls. Conclusion This systematic review is the first to report the use of antenatal corticosteroid treatment in the antenatal period. Data from a total of five studies, with 2060 and 1808 infants treated, respectively, show that this form of antenatal antenatal corticosteroid treatment generally led to better outcomes compared to placebo controls. However, it is unclear if this is an effect of a pharmacological form of corticosteroid given in the early embryo or if there is an effect of corticosteroids in the placenta. While some improvements in perinatal outcome were observed, most of the improvements were minor. This may be owing to an increased proportion of babies of low birth weight and to the increased incidence of perinatal mortality, for example, in lower birth-weight and anaemia groups. More careful evaluation of potential confounding factors such as pre-term birth, neonatal mortality, intrauterine growth restriction, and high rates of gestational diabetes and gestational hypertension must be undertaken in future studies. References 1. Mazzocchi M Jaccardi P Gallo G Peligro F Antenatal corticosteroids: impact of preterm birth and prematurity . Pediatrics 1991 ; 90 : 819 – 25 . 2. Shiffman M Gajdozkova Y Aromatase in the first month of life . Eur J Endocrinol 1999 ; 154 : 707 – 12 . 3. Gajdozkova Y Gajdozkova NA Prakovitskaya I Doyanova E , et al. Prenatal corticosteroid treatment and long-lasting effects on bone in children . J Bone Miner Res 1999 ; 14 : 1055 – 61 . 4. Ruparel G Aromatase after c-fos or c Similar articles:

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